Needle-free Insulin Therapy

A new solution in diabetes management, designed to facilitate the initiation and acceptance of insulin therapy in type 1 and type 2 diabetic patients.

Needle-free Insulin Therapy
Needle-free Insulin Therapy

A driver for therapeutic adherence

With its needle-free insulin delivery system, InsuJet provides a concrete solution to common patient problems: needle phobia, waste management, lipohypertrophy... 1 2 3

How microjet injection works

The combination of a high-pressure spring mechanism and a nozzle providing targeted penetration.

Insujet allows for complete subcutaneous administration of insulin. Its tolerability, absorption, pharmacological efficacy, and hypoglycemic effect are comparable to those achieved with conventional injections.

InsuJet delivers insulin under high pressure through an ultra-fine orifice, generating a microjet that penetrates the skin barrier and ensures uniform dispersion in subcutaneous tissue.

InsuJet generates no infectious medical waste: used consumables can be disposed of with household waste. Designed for 5,000 administrations, the injector offers an average lifespan of three years.

How microjet injection works

The advantages of microjet injection

The use of Insujet has several clinical advantages that improve adherence and outcomes of insulin therapy.

  • Microjet injection circumvents needle-phobia related effects, such as treatment anxiety or avoidance.
  • It provides an insulin absorption profile closer to endogenous insulin, enabling better early postprandial glycemic control.
  • InsuJet-administered insulin reaches peak concentration 30% faster,, regardless of BMI, allowing quicker correction of hyperglycemic episodes—particularly in overweight or obese patients.
  • Needle-free design reduces the risk of accidental injuries and infections associated with injection device handling, especially in at-risk patients.
  • Less traumatic to the skin, microjet injection also reduces the occurrence of lipohypertrophy.
  • InsuJet precisely targets the subcutaneous tissue just beneath the dermis, thereby minimizing the risk of intramuscular injection.
The advantages of microjet injection
View clinical studies

Indication and use

Insujet is indicated for the subcutaneous administration of insulin in the treatment of type 1, type 2, and gestational diabetes.

The InsuJet device is compatible with all U100 insulins (100 IU/ml). The current version allows for the administration of doses between 4 and 50 units.

  • InsuJet can be used from the age of 6, and independently by patients aged 12 and over.
  • Different insulin types should not be used in the same nozzle. If combining basal and bolus insulin, and if all injections are performed with InsuJet, two separate injectors must be used.

Support your patients in their learning

For optimal handling, the first use of InsuJet can be accompanied and carried out with physiological serum.

Injection sites

Injection sites

InsuJet™ can be used at all injection sites recommended for conventional needle-based insulin therapy4 :

Model S or M?

Why change model?

If a patient reports injections where not all of the insulin penetrates the skin with an S model (“wet injections”), it is recommended to switch to the M model, to ensure a complete injection. A patient who experiences bruising or even bleeding with an M model may opt for the less potent S model.

The adapters

The adapters

The device is compatible with all available U100 insulin types.


Two adapter types allow the use of any type of packaging:

  • Insulin vials (10 ml adapter)
  • Insulin cartridges (3 ml adapter)
  • Pre-filled pens (3 ml adapters)
The Comfort Ring

The Comfort Ring

InsuJet nozzles come with comfort rings, designed to soften contact with the skin and distribute pressure during injection.

They also facilitate optimal positioning of the injector, perpendicular to the skin surface.

A popular device

96% of surveyed users rated InsuJet as enjoyable, easy to use, or particularly effective.More than 78% said they would recommend it to others.

A simple to use device

81% of our survey participants found InsuJet easy to use from the first use, including its consumables.

Over 75% found the user manual clear and understandable from the first reading.

Finally, over 79% found consumables, such as the nozzle and adapters, easy to handle.

More effective insulin therapy

Feedback from InsuJet users corroborates the pharmacokinetic data: 70% report faster absorption of insulin with microjet injection.

Contraindications

InsuJet should not be used in patients with:

  • Significant visual impairment,
  • A physical disability that prevents proper use of the system,
  • Difficulty understanding or following instructions for use,
  • Certain skin conditions, such as psoriasis, at the injection sites.


Note: Patients with bleeding disorders should use InsuJet with caution due to an increased risk of bleeding.

Side effects

Bleeding

Very slight bleeding may occur at the injection site, especially if injected near a capillary vessel.This effect is more common in patients taking anticoagulants.

Bruiseing

Patients who frequently experience bruising with traditional needle injections may also be prone to bruising when using InsuJet. Using the comfort ring or changing the injection sites can help reduce or eliminate this undesirable effect.

In cases of bruising during the administration of large insulin doses, splitting the dose into several consecutive injections is recommended.

If bruising occurs with model M, switching to model S may help reduce it.

Infections

Very rare cases of infection may occur if the injection site becomes contaminated.Routine antiseptic cleaning of the site and regular changing of consumables are recommended to prevent this contamination.

Irritations and swellings

Patients may experience mild red swelling and irritation at the injection site.This effect often occurs at the beginning of insulin therapy and gradually disappears.

White bump at the injection site

A white bump may form at the injection site when the insulin has not penetrated deep enough into the skin.

Intramuscular injection

Accidental intramuscular injection can occur at injection sites devoid of fat, resulting in insulin being injected into the muscle.Intramuscular injections can significantly increase the variability of insulin absorption and impair glycemic control.

Pain

As with needle administration, microjet injections may cause mild pain, especially if the injection occurs near a nerve ending.

Note: Administering cold insulin may be painful.Remove the insulin from the refrigerator some time before administering it.

Scars and hardening of the skin

Less traumatic than needle injection, microjet injection can however cause the creation of fibrous tissue or lipohypertrophy.

Resources for your patients

Download the Insujet user guides to share with your patients.

Resources for your patients
  1. https://www.lequotidiendumedecin.fr/specialites/diabetologie-endocrinologie/lipodystrophie-un-piege-pour-linsuline
  2. https://www.sciencedirect.com/science/article/abs/pii/S1957255717301001
  3. https://www.sciencedirect.com/science/article/abs/pii/S1262363613001213
  4. https://www.chuv.ch/fileadmin/sites/dso/documents/Methodes_de_soins/MDS_Injection_insuline_stylo_DSO-FT_-Adultes-015.pdf