Clinical Studies

Clinical studies on needle-free injection demonstrate glycemic control benefits, particularly for postprandial glucose management and in specific diabetic patient populations.

Clinical Studies
Clinical Studies

Key Findings Explained

1.

Needle-free injection of rapid-acting insulin improves early postprandial glycemic control in diabetic patients

Engwerda EE, Tack CJ, de Galan BE. Needle-free jet injection of rapid-acting insulin improves early postprandial glucose control in patients with diabetes. Diabetes Care. 2013;36(11):3436-3441. doi:10.2337/dc13-0492

This study compares rapid-acting insulin delivery by jet (needle-free) to conventional injection with a pen, to determine whether this method improves post-meal blood sugar control in patients with type 1 and type 2 diabetes.

Faster absorption of insulin

✔ Insulin delivered by jet is absorbed more quickly than that injected with a pen.

✔ It reaches its peak action about 40 minutes earlier than with a pen.

✔This means that insulin starts working faster, helping to better control postprandial blood sugar spikes.

Better blood sugar control in the first hour after a meal

✔ Patients using the needle-free injector had lower blood sugar levels during the first hour after eating.

✔ This suggests that this method may reduce sudden spikes in blood sugar immediately after eating.

✔ However, after the first hour, blood sugar levels were similar between the two methods.

No difference in long-term glycemic control

✔ The total amount of insulin absorbed was the same for both methods.

✔ There was no significant difference in overall blood sugar levels after six hours.

✔ The study suggests that jet injection is particularly beneficial for people struggling with postprandial spikes.

Safety and comfort

✔ No major side effects were observed with the needle-free injector.

✔ Both methods were well tolerated, with similar pain levels.

✔ However, more participants preferred the traditional pen.

Who might benefit the most?

✔ The jet injector showed better early blood sugar control, which may be particularly useful for:

  • People struggling with post-meal blood sugar spikes.
  • Type 2 diabetic patients, who seemed to benefit slightly more from this method.
  • People with needle phobia, as this is a needle-free option.

Conclusion

Needle-free injection allows insulin to act faster, providing better glycemic control immediately after meals. However, it is not necessary for everyone and requires proper training.

If you struggle with post-meal blood sugar control, talk to your doctor to see if InsuJet could be a suitable option for your insulin therapy!

2.

Needle-free injected insulin corrects severe hyperglycemia faster in overweight or obese diabetic patients

de Wit HM, Engwerda EE, Tack CJ, de Galan BE. Insulin administered by needle-free jet injection corrects marked hyperglycaemia faster in overweight or obese patients with diabetes. Diabetes Obes Metab. 2015;17(11):1093-1099. doi:10.1111/dom.12550

This study examined whether needle-free insulin administration could correct hyperglycemia faster than a traditional insulin pen, particularly in overweight or obese diabetic patients. Here's what you need to know:

Jet injection reduces high blood sugar faster

✔ Needle-free injector-administered insulin worked faster than an insulin pen in overweight or obese patients.

✔ It took about 45 minutes less to reduce blood sugar by 10 mmol/L with the jet injector compared to the pen.

✔ The improvement was even more pronounced in patients with higher body weight.

Faster insulin absorption

✔ Insulin peaked in blood at 40 minutes with the jet injector versus 77 minutes with the insulin pen.

✔ This means insulin starts working faster, helping to reduce blood sugar more quickly.

Less time spent in hyperglycemia

✔ Total time spent in hyperglycemia was reduced with the jet injector, especially in the two hours following injection.

✔ This may help prevent complications related to prolonged hyperglycemia.

No increased hypoglycemia risk

✔ Despite its faster action, the jet injector did not increase hypoglycemia risk.

✔ Patients didn't need to consume more glucose after using the jet injector compared to the insulin pen.

Patient comfort and preference

✔ Patients rated both devices as equally comfortable and easy to use.

✔ 6 people preferred the jet injector,

✔ 7 preferred the insulin pen,

✔ 7 had no preference.

Who might benefit most?

✔ Type 1 or type 2 diabetics who are overweight or obese.

✔ Those needing rapid hyperglycemia correction, e.g. after missed doses or meal adjustments.

✔ People experiencing insulin absorption difficulties due to body weight.

Conclusion

If you're overweight/obese on insulin therapy, a jet injector may help correct hyperglycemia faster than traditional pens. It works faster, reduces blood sugar quicker, with no increased hypoglycemia risk. If you experience frequent high blood sugar spikes or delayed insulin action, this may be an option worth discussing with your doctor!

3.

Body mass index and the efficacy of needle-free jet injection for the administration of rapid-acting insulin analogs, a post hoc analysis.

de Galan BE, Engwerda EE, Abbink EJ, Tack CJ. Body mass index and the efficacy of needle-free jet injection for the administration of rapid-acting insulin analogs, a post hoc analysis. Diabetes Obes Metab. 2013;15(1):84-86. doi:10.1111/j.1463-1326.2012.01666.x

This study examined the impact of body weight (BMI) on rapid-acting insulin absorption when administered via needle-free injector versus traditional insulin pen. Here are the key findings:

Insulin absorption is slower in overweight individuals using insulin pens

✔ Individuals with high BMI experience slower insulin absorption when using traditional insulin pens.

✔ Time to peak insulin levels was 31 minutes longer in overweight individuals compared to those with lower BMI.

✔ The delay before insulin began reducing blood sugar was nearly one hour longer in overweight pen users.

Needle-free injectors work equally well across all body types

✔ With needle-free injectors, insulin absorption was identical in lean and overweight individuals.

✔ This suggests needle-free technology enables faster insulin action regardless of body fat percentage.

Faster insulin action with needle-free injection in overweight individuals

✔ Time to peak insulin absorption was reduced by 47 minutes in overweight needle-free injector users.

✔ Time to maximal blood sugar reduction effect was nearly 80 minutes faster with needle-free injectors versus pens.

Why is this important for you?

✔ If you have high BMI and struggle with post-meal blood sugar control, needle-free injectors may enable faster, more effective insulin action.

✔This could reduce postprandial blood sugar spikes and limit late hypoglycemia risk.

No safety concerns

✔ The study reported no adverse effects or skin reactions with needle-free injectors.

✔ Insulin absorption was reliable and consistent regardless of body weight.

Conclusion

If you're overweight/have high BMI, needle-free injectors may accelerate insulin action versus traditional pens, improving post-meal glucose control and reducing fluctuations.

If experiencing these challenges, consult your doctor about whether InsuJet might be right for you!

4.

A pilot study to examine the tolerability and device preference in type 1 diabetes of insulin aspart administered by InsuJet compared with subcutaneous injection

Reutens AT, Balkau B, Cohen N. A pilot study to examine the tolerability and device preference in type 1 diabetes of insulin aspart administered by InsuJet compared with subcutaneous injection. Diabetes Technol Ther. 2014;16(4):235-240. doi:10.1089/dia.2013.0250

This study compares needle-free insulin administration (jet injection) to traditional insulin pen injection in type 1 diabetic patients. The objectives were to evaluate tolerability, patient preference, and postprandial glycemic efficacy. Here are the main findings:

Blood glucose control is similar with both devices

✔ No significant difference in postprandial blood glucose levels whether insulin was administered via needle-free injection or insulin pen.

✔ Both methods provided effective postprandial glucose control over a 4-hour period.

Insulin absorption is comparable

✔ Blood insulin levels remained similar for both devices throughout the study.

✔ Insulin peaked faster with needle-free injector (30 min) vs pen (60 min), but overall absorption remained the same.

No major side effects or safety concerns

✔ Needle-free injector was well tolerated, with no reports of significant bruising or pain.

✔ No serious adverse effects were observed with either device.

Patients showed no strong preference between methods

✔ 4 participants preferred needle-free injector.

✔ 2 preferred insulin pen.

✔ 4 liked both methods equally.

✔ Pain perception was similar between devices.

What this means for you

✔ If you're needle-phobic, needle-free injector may be a comfortable, effective alternative.

✔ Insulin pens remain equally effective and may be easier for those accustomed to them.

✔ Both methods provide good glucose control - choice depends on personal preference.

Conclusion

InsuJet and traditional insulin pens provide equivalent postprandial glucose control in type 1 diabetes. No major differences were found in insulin absorption, side effects or pain.

If considering switching from pens to InsuJet, consult your doctor to see if it's right for you!

5.

Improved pharmacokinetic and pharmacodynamic profile of rapid-acting insulin using needle-free jet injection technology

Engwerda EE, Abbink EJ, Tack CJ, de Galan BE. Improved pharmacokinetic and pharmacodynamic profile of rapid-acting insulin using needle-free jet injection technology. Diabetes Care. 2011;34(8):1804-1808. doi:10.2337/dc11-0182

This study compares needle-free insulin delivery (jet injection) to traditional insulin pens. Here are the key takeaways:

Faster insulin absorption

✔ Jet injector delivers insulin into the body faster than insulin pens.

✔ This means blood glucose starts decreasing sooner after injection.

Better postprandial glucose control

✔ Faster-acting insulin better matches food absorption.

✔ Helps avoid post-meal blood sugar spikes.

Shorter insulin duration

✔ Jet-injected insulin remains active for shorter duration than pen-injected.

✔ May reduce risk of late hypoglycemia.

How jet injection works?

✔ High-speed insulin spray under skin enables more even distribution.

✔ Enhanced dispersion optimizes absorption for faster action.

Study results

✔ Time to peak insulin levels was halved with jet injector vs pen.

✔ Insulin levels rose faster, making it more effective for rapid glucose reduction.

Is jet injection better?

✔ May more closely mimic natural insulin action.

✔ Particularly helpful for those with post-meal glucose spikes.

✔ However, requires proper training for use.

Conclusion

If using rapid-acting insulin, needle-free injector may help control blood sugar faster and more effectively.

Discuss with your doctor whether this option suits you!